Malaysian Airlines Flight HM370, carrying 239 people from Kuala Lumpur to Beijing, went missing over the South China Sea about two hours after taking off. No signs of the plane's location or possible crash site have been found, other than two oil slicks spotted by Vietnamese air force pilots. The passengers included over 150 Chinese and 4 Americans.
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UPDATE: According to Fox News, two people on board the plane have been reported to possess stolen passports.